Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions
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چکیده
منابع مشابه
Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions.
Psoriasis is a chronic inflammatory skin disease in which epidermal hyperplasia results from skin infiltration by type I T lymphocytes and release of associated cytokines. A multifunctional cytokine, rhIL-11, modulates macrophage and type I T-lymphocyte function in cell culture and shows anti-inflammatory activity in animal models. We are testing subcutaneous delivery of rhIL-11 to patients wit...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1999
ISSN: 0021-9738
DOI: 10.1172/jci6910